FP7 logo euThe ESNATS project has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° HEALTH-F5-2008-201619

Embryonic Stem cell-based Novel Alternative Testing Strategies

Glossary

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3R principle
3R stands for reduction, refinement and replacement of animal experiments
Alternative testing
Toxicological testing that replaces animal tests by e.g. cell culture tests
Embryonic stem cells
Cells that are derived from the inner cell mass of blastocyst-stage embryos and that can differentiate into all cell types of the body
In vitro-toxicology
Toxicological studies using e.g. cell culture or organ cultures rather than living organisms for studying toxicity of test substances
Metabolic systems
Cells or cell fractions capable of metabolising test substances
Neurotoxicity
Toxicity affecting the cells of the nervous system
REACH
European Community regulation regarding the Registration, Evaluation, Authorisation and Restriction of CHemical substances.
Reproductive toxicity
Toxicity affecting the reproductive system of an organism
Toxicogenomics
Application of genomics tools (e.g. gene expression profiling) to toxicological studies. Together with classiscal toxicological tests and toxicoproteomics, toxicogenomics can offer mechanistic insights or help predict a novel substance’s toxicological properties
Toxicology
The study of toxic effects of substances on living organism
Toxicoproteomics
Application of proteomics tools (e.g. phosphoproteomics) to toxicological studies. Together with classiscal toxicological tests and toxicogenomics, toxicoproteomics can offer mechanistic insights or help predict a novel substance’s toxicological properties
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