FP7 logo euThe ESNATS project has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° HEALTH-F5-2008-201619

Embryonic Stem cell-based Novel Alternative Testing Strategies

Scientific publications

ESNATS publications

Other publications related to the ESNATS research

  • Hengstler JG, Stewart JD, Bolt HM, "Epoxide hydrolases are not only a molecular sponge sucking up genotoxic epoxides: new roles in control of blood pressure, inflammation as well as nociception and cell proliferation" (Arch Toxicol,04/09,83(4):289-9) (http://www.ncbi.nlm.nih.gov/pubmed/19333580)
  • Riquelme P., Wundt J, Hutchinson JA, Brulport M, Sotnikova A, Girreser U, Braun F, Gövert F, Soria B, Nüssler A, Clement B, Hengstler JG, Fändrich F, "A refined characterisation of the NeoHepatocyte phenotype necessitates a reappraisal of the transdifferentiation hypothesis." (Differentiation, 03/09,77(3):263-76) (http://www.ncbi.nlm.nih.gov/pubmed/19272525)
  • Bolt HM, Marchan R, Hengstler JG, "Low-dose extrapolation in toxicology: an old controversy revisited" (Arch Toxicol., 03/09,83(3):197-8) (http://www.ncbi.nlm.nih.gov/pubmed/19247634)
  • Schumann A, Bauer A, Hermes M, Gilbert M, Hengstler JG, Wilhelm C, "A rapid and easy to handle thermoluminescence based technique for evaluation of carbon tetrachloride-induced oxidative stress on rat hepatocytes" (Arch Toxicol., 12/02/09) (http://www.ncbi.nlm.nih.gov/pubmed/19214477)
  • Hengstler JG, Godoy P, Bolt HM, "The dilemma of cultivated hepatocytes" (Arch Toxicol., 02/09, 83(2):101-3) (http://www.ncbi.nlm.nih.gov/pubmed/19183961)
  • Aurich H, Sqodda M, Kaltwasser P, Vetter M, Weise A, Liehr T, Brulport M, Hengstler JG, Dollinger MM, Fleig WE, Christ B, "Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo"(Gut., 04/09, 58(4):570-81) (http://www.ncbi.nlm.nih.gov/pubmed/19022918)
  • Borza A, Plöttner S, Wolf A, Behm C, Selinski S, Hengstler JG, Roos PH, Bolt HM, Kuhlmann J, Föllmann W, "Synergism of aromatic amines and benzo[a]pyrene in induction of Ah receptor-dependent genes" (Arch Toxicol. 12/08, 82(12):973-80)
  • Lilienblum W, Dekant W, Foth H, Gebel T, Hengstler JG, Kahl R, Kramer PJ, Schweinfurth H, Wollin KM, "Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH)" (Arch Toxicol., 04/08, 82(4):211-36) (http://www.ncbi.nlm.nih.gov/pubmed/18322675)
  • Hengstler JG, Bolt HM, "The past and the future of toxicology" (Arch Toxicol., 01/08, 82(1):1-3) (http://www.springerlink.com/content/0m7532x676m17883)
  • Hengstler JG, Bolt HM, "Induction and control of oxidative stress" (Arch Toxicol., 12/07, 81(12):823-4)
  • Schug M, Heise T, Bauer A, Storm D, Blasskewicz M, Bedawy E, Brulport M, Geppert B, Hermes M, Föllmann W, Rapp K, Maccoux L, Schormann W, Appel KE, Oberemm A, Gundert-Remy U, Hengstler JG, "Primary rat hepatocytes as in vitro system for gene expression studies: comparison of sandwich, Matrigel and 2D cultures" (Arch Toxicol., 12/08, 82(12):923-31) (http://www.ncbi.nlm.nih.gov/pubmed/18987846)
  • Bolt H.M, Hengstler JG, "The debate about possibilities and limitations of in vitro toxicity tests and replacement of in vivo Studies" (Arch Toxicol.,12/08, 82(12):881-3) (http://www.ncbi.nlm.nih.gov/pubmed/18987845?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
  • Bolt HM, Hengstler JG, "Aluminium and lead toxicity revisited: mechanisms explaining the particular sensitivity of the brain to oxidative damage" (Arch Toxicol, 11/08, 82(11):787-8) (http://www.ncbi.nlm.nih.gov/pubmed/18830583)
  • Hengstler JG et al., "Failure in drug development: the role of inhibition and induction of cytochrome P450 enzymes" (Arch Toxicol., 10/08, 82(10):665-6)
  • Degen GH, Hengstler JG, "Developments in industrial and occupational toxicology: REACH, toxicogenomics, mycotoxins, lead, asbestos, boron, bitumen, deletions polymorphisms and SNP interactions: meeting report of the 16th EUROTOX training and discussion session" (Arch Toxicol., 07/08-Epub 2008 May 21, 82(7):483-7) (http://www.ncbi.nlm.nih.gov/pubmed/18493747)
  • Hengstler JG, Bolt HM, "Oxidative stress: from modification of cell-cycle related events, secondary messenger function, dysregulation of small GTPases, protein kinases and phosphatases to redox-sensitive cancer models" (Arch Toxicol., 05/08, 82(5):271-2) (http://www.ncbi.nlm.nih.gov/pubmed/18438644)
  • Hengstler JG, Bolt HM, "Loss of DNA damage checkpoint genes: switch from preferential induction of point mutations to chromosomal damage precedes the transition towards an aggressive cancer type" (Arch Toxicol., 05/08, 82(6):341-2) (http://www.ncbi.nlm.nih.gov/pubmed/18350279)
  • Leist M, et al., "The Biological and Ethical Basis of the Use of Human Embryonic Stem Cells for In Vitro Test Systems or Cell Therapy" (ALTEX 25, 3/08, 163-190) (http://www.altex.ch/resources/ALTEX_3_08_Leist1.pdf)
  • Leist M, Hartung T, Nicotera P. The dawning of a new age of toxicology. ALTEX. 2008; 25(2):103-14.
  • Leist M, Kadereit S, Schildknecht S. Food for thought... on the real success of 3R approaches. ALTEX. 2008; 25(1):17-32.
  • De Kock J, Vanhaecke T, Rogiers V, Snykers S., Chromatin remodelling, a novel strategy to expedite the hepatic differentiation of adult bone marrow stem cells in vitro. AATEX 2008, 14:605-611
  • Snykers S, Vanhaecke T, De Becker A, Papeleu P, Vinken M, Van Riet I, Rogiers V., Chromatin remodelling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bonemarrow. BMC Dev Biol. 2007, 7:24
  • Massip L, Ectors F, Deprez P, Maleki M, Behets C, Lengelé B, Delahaut P, Picard J, Rezsöhazy R. Expression of Hoxa2 in cells entering chondrogenesis impairs overall cartilage development. Differentiation. 2007, 75(3):256-67.
  • Guan K *, Nayernia K* , Maier LS, Wagner S, Dressel R, Lee JH, Nolte J, Wolf F, Li M, Engel W, Hasenfuss G. Pluripotency of spermatogonial stem cells from adult mouse testis. Nature 440: 1199-1203 (2006) (* joint first authors).
  • Nayernia K, Nolte J, Michelmann HW, Lee JH,  Rathsack K, Drusenheimer N, Schwandt I, Wulf G, Ehrmann I, Elliott DJ, Zechner U , Haaf T, Meinhardt A, and Engel W. In vitro Differentiated Embryonic Stem Cells Give Rise to MaleGametes That Can Generate Offspring Mice. Developmental Cell 11:125-32 (2006).
  • Nayernia K, Lee JH, Drusenheimer N, Nolte J, Wulf G, Schwandt I, Müller Ch, Gromoll J, Engel W. Derivation of germ cells from bone marrow stem cells. Lab Investigation 86: 654-656 (2006).
  • Lee, J.H., Engel, W., Nayernia, K.: Stem Cell Protein Piwil2 Modulates Expression of Murine Spermatogonial Stem Cell Specific Genes. Molecular Reproduction and Development 73: 173-179 (2006).
  • Bruce, D. Stem Cells, Embryos and Cloning - Unravelling the Ethics of a Knotty Debate, Journal of Molecular Biology, vol.319, 2002, pp.917-925.
  • Bruce, D. and Bruce, A. (eds.), Engineering Genesis (Earthscan, London), especially chapter 4 on Animal Welfare, 1998, pp. 110-126 and chapter 5 on Animal Ethics and Human Benefit, pp.127-158.
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