Partners: Vrije Universiteit Brussel (VUB)
The Department of Toxicology (FAFY) is particularly specialised in the development of organotypic long-term culture models of both primary and adult stem cell-derived hepatocytes for pharmaco-toxicological purposes. Recently, the group has entered a patent proposal for the use of histone deacetylase inhibitors in order to (i) stabilise the phenotype of primary cells in culture and (ii) to differentiate adult bone marrow stem cells as well as rat liver epithelial cells into mature hepatocytes (PCT/EP2004/0012134 and PCT/EP2006/005622). FAFY will scientifically contribute to the phenotypic characterisation (metabolic competence) of the human ES- and adult stem cell-derived hepatocytes in order to compare their metabolic competence towards primary human hepatocytes.
Key staff involved in the project
Vera Rogiers, Prof PhD Pharm, head of the Department of Toxicology, Dermato-Cosmetology and Pharmacognosy at the VUB. She is full-time professor toxicology and organises on a regular basis postgraduate courses on risk assessment in Europe of cosmetic ingredients and finished products. Her main research activity concerns the development of in vitro models for pharmaco-toxicological purposes. She is author of more than 200publications in peer-reviewed journals and has obtained 5 scientific awards, among these the Doerenkamp-Zbinden Award and the P&G/Eurotox/Humane Society Award. She is co-chair of the SCCP, member of ESAC, chairperson of ecopa and member of the epaa mirror group.
Tamara Vanhaecke, Prof PhD Ir, work leader of the Department of Toxicology, Dermato-Cosmetology and Pharmacognosy at the VUB. She is part-time lecturer toxicology and post-doctoral researcher. Her specific area of research concerns xenobiotic biotransformation, long-term culture of functional hepatocytes and in particular the involvement of epigenetic mechanisms in the maintenance of the differentiated state (metabolic competence) of hepatocytes during culture. She has more than 50 scientific publications in peer-reviewed journals and books and is reviewer for several scientific journals in the field of toxicology and 3R-alternatives. She obtained the Scientific Award of the Foundation Prince Louis de Polignac, Paris for her research on 3R-alternatives. She is responsible for the follow-up of several research projects within the group.
Joery De Kock, Pharm. is a PhD student at the Department of Toxicology, Dermato-Cosmetology and Pharmacognosy (VUB). His core skills are situated in the field of molecular biology, in vitro experimental toxicology, and progenitor cell isolation and culture. He particularly focuses on the effects of chromatin remodelling on hepatic trans-differentiation of human postnatal skin progenitor cells (SKP). Evi De Prins, Pharm. is a starting PhD student at the Department of Toxicology, Dermato-Cosmetology and Pharmacognosy (VUB). She will be involved in the isolation and culture of human adipose tissue-derived stem cells (ADSC). Her interest is particularly focused on the study of the hepatic potential of ADSC.
Evi De Prins, Pharm. is a starting PhD student at the Department of Toxicology, Dermato-Cosmetology and Pharmacognosy (VUB). She will be involved in the isolation and culture of human adipose tissue-derived stem cells (ADSC). Her interest is particularly focused on the study of the hepatic potential of ADSC.
Further information: http://minf.vub.ac.be/~fafy/
Prof. Vera Rogiers
Dept. of Toxicology Dermato-Cosmetology and Pharmacognosy
Faculty of Medicine and Pharmacy
Vrije Universiteit Brussel
B-1090 Brussel, Belgium