Partners: The University of Edinburgh (UEDIN)
The SCRM at UEDIN, directed by Prof. Ian Wilmut, covers a spectrum of basic and translational clinical research on stem cells and their use in regenerative medicine. It provides state-of-the-art facilities for stem cell manipulation from human and mouse embryonic, fetal and adult tissues. This includes capacities in mouse transgenesis, animal cloning confocal and time lapse microscopy, operator run Flow cytometry (sorting and analysis), Bioinformatics, Quantitative (real time) PCR, Automated in situ hybridisation and Histology. Over £55 M in funding was recently secured for new facilities to be available in 2010, which will contain a Good Manufacturing Practice grade facility for clinical delivery of cells. UEDIN will contribute to Reproductive Toxicology (RT) (SP1, WP1.3 & 1.5) and Central (CWP0.3) work packages. All research will be carried out in Dr Paul De Sousa's laboratory building on his group's expertise in human embryo stem cells (hESC), complimented by collaborative expertise in bioinformatics (Tomlinson) and implantation (Jabbour). Specifically, UEDIN will develop hESC based platforms to epigenetically profile (1.5) and model trophoblast response (1.3) using hESCs, in addition to defining cell culture requirements underpinning their automated expansion.
Key staff involved in the project
Paul A. De Sousa, Dr., Senior Research Fellow, SCRM Uof E, is a developmental biologist who has worked on basic and applied aspects of early mammalian embryology. As a Roslin Institute group leader (1998-2005) his research focused on animal cloning and hESC isolation. Since 2005, his U of E lab has focused on hESCs biology underpinning their applied used in regenerative medicine and industry.
Henry Jabbour, Dr., Programme Leader, MRC Human Reproductive Sciences Unit, Honorary Lecturer, U of E. is a reproductive endocrinologist, whose research is focused on understanding endometrial regulation of vascular function in health and disease. His current interests are aimed at control of trophoblast/endometrial signalling during implantation.
Simon Tomlinson, Dr., Group Leader, SCRM, U of E, is a bioinformatician whose group is focused on understanding the molecular features of stem cell biology. Dr Tomlinson was responsible for developing the new European stem cell database, StemDB, for the EuroStemCell project, serving as an information storage hub for the stem cell community.
Further information: www.scrm.ed.ac.uk
Paul A. De Sousa PhD MSc
Senior Research Fellow
Centre for Regenerative Medicine
College of Medicine and Veterinary Medicine
University of Edinburgh
Chancellor's Building, Rm GU.531
49 Little France Crescent