Partners: Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek (TNO)
TNO is an independent research organisation bridging technological developments into practical applications for industry and government. TNO will contribute to the ESNATS project with physiologically-based pharmacokinetic modelling by extrapolating in vitro toxicology data to in vivo and integrating kinetics of the compounds. We will use our experience in PBPK modelling, in vitro and in vivo ADME and in vitro toxicology studies (with e.g. embryonic stem cells), link with genomics data and reproduction and neuro toxicology.
Key staff involved in the project
Miriam Verwei, PhD, obtained her phD in 2004 on the prediction of the bioavailability of folate in man using an integrated approach of in vitro studies and kinetic modelling. In 2004 she joined the pharmacokinetics department of TNO after which she worked as a scientist and project manager within many (inter)national projects with industry, government and universities. She is involved in several research projects on the extrapolation of 1) data from in vitro toxicity studies to predict in vivo effect levels and 2) data from in vitro kinetic studies to predict plasma levels and tissue concentrations in rodents and man.
Joost Westerhout, MSc, is experienced in mathematical and statistical modeling applied to pharmacology. He has finished a PhD project in pharmacology at the Leiden/Amsterdam Center for Drug Research on the regional distribution of drugs in rat brain with intracerebral microdialysis and physiologically based pharmacokinetic (PBPK) modeling. He joined TNO as a scientist to develop translational PBPK models for in vitro-in vivo extrapolation of prenatal neurotoxicity and reproductive toxicity.
Sieto Bosgra, PhD, is experienced in mathematical and statistical modelling applied to pharmacology and toxicology. He obtained his PhD in toxicology at Utrecht University's Institute for Risk Assessment Sciences on quantitative methods to predict combined effects of chemicals. As a postdoctoral fellow at the Dutch National Institute of Public Health and the Environment, he developed a generic PBPK model framework to gain insight in the interrelation between physiology, chemical properties and pharmacokinetics. He joined TNO as a scientist pharmacokinetics among others to develop translational methods for in vitro-in vivo extrapolation.
Further information: TNO - Pharma